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Previous Volume 331:1286-1292 November 10, 1994 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Progressive fibrosis in the kidney, liver, lung, heart, bone marrow, and skin is both a major cause of suffering and death and an important contributor to the cost of health care. All of this is likely to change in the future. Advances in cell and cytokine biology have brought a new understanding of the molecular events underlying tissue fibrosis. It is becoming clear that fibrogenesis is not a unique pathologic process but is due to excesses in the same biologic events involved in normal tissue repair¹.

A central event in tissue repair is the release of cytokines in response . . . [Full Text of this Article]

Cytokines in Tissue Injury

Biologic Actions of TGF- in Tissue Repair

Enhancement of Wound Healing by TGF-

TGF- in Fibrotic Diseases

Kidney

Lung

Fibrotic Disorders of Other Organs

Overproduction of TGF- in Fibrosis

TGF- Antagonists as Antifibrotic Agents

Conclusions

Source Information

From the Division of Nephrology, University of Utah School of Medicine, 50 N. Medical Dr., Salt Lake City, UT 84132, where reprint requests should be addressed to Dr. Border.

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