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Previous Volume 331:129-130 July 14, 1994 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The article by Svensson and Dahlback on resistance to activated protein C (APC) (Feb. 24 issue)¹ postulates that there is a genetically determined defect in anticoagulation characterized by resistance to APC. The authors subsequently found the anticoagulant cofactor that corrects inherited APC resistance to be identical to unactivated factor V. I believe that these findings could also be due to hyperhomocysteinemia. It has been demonstrated that hyperhomocysteinemia is an independent risk factor for vascular disease^2,3. It was previously demonstrated that homocysteine induced a vascular-endothelial-cell activator that led to the activation of factor V⁴. I feel . . . [Full Text of this Article]

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