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Previous Volume 331:134-135 July 14, 1994 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Saccharin is not known to alter liver function^1,2,3,4. We report on a patient who had elevated serum concentrations of liver enzymes after the oral administration of three different drugs, of which saccharin was the only common constituent. Reexposure to pure saccharin supported its role in the pathogenesis of liver damage in this patient.

A 70-year-old woman being evaluated for chronic fatigue was found to have increased levels of serum aspartate aminotransferase (306 U per liter), alanine aminotransferase (247 U per liter), -glutamyltransferase (1000 U per liter), and alkaline phosphatase (478 U per liter). The patient had . . . [Full Text of this Article]

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