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Previous Volume 331:1428-1436 November 24, 1994 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Insulin-dependent diabetes mellitus (IDDM) is a chronic disorder that results from autoimmune destruction of the insulin-producing pancreatic beta cells. Much has been learned during the past decade about the underlying genetics, natural history, and pathogenesis of IDDM. In this review, we shall describe some of this new information and discuss how it might be used to prevent the disease.

Epidemiology

IDDM occurs most frequently in persons of northern European descent. Among other racial groups, such as blacks, Native Americans, and Asians, the disease is less common¹. The incidence ranges from a low of 1 to 2 per 100,000 per year . . . [Full Text of this Article]

Genetics

Pathogenesis and Natural History

Insulitis

Autoantibodies and Metabolic Markers of Disease

Islet-Cell Antigens

Cellular Immunity and Mediators of Inflammation

The Autoimmune Basis of IDDM

Intervention Strategies

Conclusions

Source Information

From the Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, Gainesville.

Address reprint requests to Dr. Atkinson at the University of Florida, JHMHC Box 100275, Gainesville, FL 32610.

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