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Previous Volume 331:1459-1460 November 24, 1994 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Offit, K.

To the Editor: In his editorial on the article by Offit and colleagues (July 14 issue),¹ Kluin² concludes that "it is intriguing that activation of the bcl-6 gene seems to be disadvantageous to lymphoma cells: movement of the gene to a new chromosome apparently curtails the malignant behavior of the tumor." Kluin confronts us with a riddle, because it is difficult to see how any disadvantageous mutation in a malignant cell could lead to a clonal overgrowth of that cell and its progeny.

There is no need to conclude that bcl-6 "curtails the malignant behavior of the tumor." Genotypically, diffuse . . . [Full Text of this Article]

References

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