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Previous Volume 331:1564-1575 December 8, 1994 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Idiopathic dilated cardiomyopathy (IDC) is a primary myocardial disease of unknown cause characterized by left ventricular or biventricular dilatation and impaired myocardial contractility¹. Depending on the diagnostic criteria used, the reported annual incidence varies between 5 and 8 cases per 100,000 population^2,3,4,5. However, the true incidence is probably underestimated by those figures, since many asymptomatic cases remain unrecognized. The age-adjusted prevalence of IDC in the United States averages 36 cases per 100,000 population,⁵ and it accounts for 10,000 deaths annually².

Blacks and males have a 2.5-fold increase in risk, as compared with whites and females, that is . . . [Full Text of this Article]

Pathological Features

Clinical Features and Natural History

Clinical Presentation

Natural History

Predictors of Mortality

Pathogenesis

Familial and Genetic Factors

Viral Myocarditis and Other Cytotoxic Insults

Immune Abnormalities

The Role of the Sympathetic Nervous System

Diagnostic Evaluation

Possible Causes

The Physical Examination

The Chest Film and Electrocardiographic Findings

Noninvasive Studies

Invasive Studies

Treatment

Supportive Therapy

Vasodilators

Anticoagulation

Antiarrhythmic Therapy

Positive Inotropic Agents

Beta-Blocking Agents

Immunosuppression and Other Forms of Therapy

Cardiac Transplantation

Conclusions

Source Information

From the Cardiac Unit, Bulfinch 211, Massachusetts General Hospital, Boston, MA 02114, where reprint requests should be addressed to Dr. Dec.

References

Related Letters:

Idiopathic Dilated Cardiomyopathy
Cooke C. E., Greenberg M. D., Coughlin S. S., Mishark K., Odawara M., Yamashita K., Legha S. S., Dec G.W., Fuster V.
Extract | Full Text  
N Engl J Med 1995; 332:1384-1386, May 18, 1995. Correspondence

Dilated Cardiomyopathy in HIV-Infected Patients
Chariot P., Perchet H., Monnet I., Malnick S., Goland S., Flotats A., Domingo P., Carrió I., Barbaro G., Barbarini G., Miller T. L., Lipshultz S. E.
Extract | Full Text  
N Engl J Med 1999; 340:732-735, Mar 4, 1999. Correspondence

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