FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 331:1590-1591 December 8, 1994 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Uren, N. G. PubMed Citation

To the Editor: Uren et al. (July 28 issue)¹ conclude that the coronary vasodilator response is severely impaired after myocardial infarction, in both infarcted and uninfarcted myocardial regions. However, the results of their studies are complicated by other important changes that occur during and after myocardial infarction, which were not considered.

Dipyridamole is a basic, lipophilic drug that is extensively and avidly bound to serum protein and has a relatively high rate of clearance.² At relevant concentrations, over 99 percent of dipyridamole is bound to 1-acid glycoprotein.² Myocardial infarction causes dramatic (over twofold) time-dependent increases in the concentrations of this . . . [Full Text of this Article]

References

HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  HELP  |  beta.nejm.org Comments and questions? Please contact us. The New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.