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Previous Volume 331:1591-1592 December 8, 1994 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their study of the correlation between the allelic loss of chromosome 18q and survival among patients with colorectal cancer (July 28 issue),¹ Jen et al. used microsatellite polymorphisms to distinguish between two alleles in tumor DNA. A "relative intensity of the two alleles in the tumor DNA [that] differed from the relative intensity in the non-neoplastic tissue DNA by a factor of at least 1.5" was used as the criterion for loss of heterozygosity.² However, this criterion is not stringent enough to support the loss of heterozygosity in some cases of liver cancer.

We used 12 . . . [Full Text of this Article]

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