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Correction to Greenberg et al., N Engl J Med 331(3):141-147 July 21, 1994.

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Volume 331:1720-1721 December 22, 1994 Number 25
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Antioxidant Vitamins and Colorectal Adenoma

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by Greenberg, E. R.
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by Greenberg, E. R.
To the Editor: Greenberg et al. (July 21 issue)1 report negative results when three antioxidant vitamins (beta carotene, vitamin C, and vitamin E) were given over a four-year period to test their efficacy in preventing colorectal adenoma, a surrogate outcome for colorectal cancer. The authors suggest that the three-year period between the colonoscopic examinations at year 1 and year 4 may not have been long enough for a change in the incidence of adenoma to be observed and that the interventions used may not have been the correct ones to reduce the incidence. A third explanation is that the interventions . . . [Full Text of this Article]

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