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Previous Volume 331:1777-1778 December 29, 1994 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Burke et al. (Aug. 11 issue)¹ concluded from their retrospective study that cyclosporine does not cause progressive toxic nephropathy in renal-transplant recipients. Their analysis of 1663 recipients revealed remarkable stability in serum creatinine concentrations during a follow-up of 54 months. However, cyclosporine was discontinued in 149 of the 1663 patients for a variety of reasons, including nephrotoxicity, chronic graft dysfunction, and the physician's preference. When did these patients stop taking cyclosporine, and what happened to their renal function thereafter? Did the mean serum creatinine concentration during follow-up change when the results in the 149 patients who stopped . . . [Full Text of this Article]

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