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Correspondence
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Volume 331:335-336 August 4, 1994 Number 5
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Continuous Intraarterial Measurement of Oxygenation during Aerosolized Prostacyclin Administration in Severe Respiratory Failure

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To the Editor: A recent report1 stimulated us to use aerosolized prostaglandin I2 (PGI2; also called prostacyclin or epoprostenol) to improve arterial oxygenation by producing selective pulmonary vasodilation in well-ventilated areas. PGI2 decreases microvascular pressure in the lung and reduces pulmonary fluid filtration and right-heart afterload2.

We report here on a 65-year-old patient with severe respiratory failure due to pneumonia (Klebsiella pneumoniae infection) and pulmonary hypertension. The chest film showed extensive bilateral interstitial infiltrates, signs of a "capillary leak syndrome," and atelectasis. Because of critically decreased oxygenation, we inserted a sensor into the left radial artery and connected . . . [Full Text of this Article]

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