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Correspondence
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Volume 331:404-405 August 11, 1994 Number 6
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HLA Compatibility and Graft Survival after Heart Transplantation

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 by Opelz, G.
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To the Editor: Opelz and Wujciak and their colleagues are to be congratulated for maintaining a multicenter registry in the Collaborative Transplant Study (March 24 issue)1. However, before their recommendations for realigning the organ-delivery system are implemented, they must first prove that the degree of HLA mismatching has an effect on the incidence and severity of the serious complication graft arteriosclerosis, which currently limits long-term survival of heart-transplant recipients2.

Furthermore, it is unrealistic to propose that 20 percent of organs can be safely set aside for emergency transplantations. As has been shown, the overall trend is for transplantation . . . [Full Text of this Article]

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