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Original Article
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Volume 331:439-442 August 18, 1994 Number 7
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Organic Osmolytes in the Brain of an Infant with Hypernatremia
Jung Hee Lee, Edgardo Arcinue, and Brian D. Ross

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Neurologic symptoms due to electrolyte disorders are common, occurring in patients with diarrhea, diabetes mellitus, head injury, renal failure, and many other disorders, especially in infants and the elderly. The clinical syndromes of dehydration and overhydration, often first detected in measurements of plasma sodium or osmolality, are among the most frequent causes of the neurologic symptoms, which include irritability, seizures, lethargy, and coma. There are multiple hormonal and neurogenic mechanisms to maintain total body water and the concentration of solutes (osmolality) within narrow limits. Interruption of these homeostatic mechanisms leads to the retention or loss of either water or solute; . . . [Full Text of this Article]

Methods

Patient

Proton NMR Spectroscopy

Results

Discussion


Source Information

From the Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institutes (J.H.L., B.D.R.); and Huntington Memorial Hospital (E.A.) -- both in Pasadena, Calif.

Address reprint requests to Dr. Ross at Huntington Medical Research Institutes, 660 S. Fair Oaks Ave., Pasadena, CA 91105.

References


Related Letters:

Organic Osmolytes in the Brain of an Infant with Hypernatremia
Schulman M., Lee J. H., Arcinue E., Ross B. D.
Extract | Full Text  
N Engl J Med 1994; 331:1776-1777, Dec 29, 1994. Correspondence

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