Inflammation and Coronary Artery Disease

doi:10.1056/NEJM199408183310709

Volume 331:468-469		August 18, 1994		Number 7

Inflammation and Coronary Artery Disease

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Recent research suggests that focal inflammation in the coronaryarteries may be involved in the genesis of unstable coronarysyndromes. In this issue of the Journal, Liuzzo et al.¹ reportthat the acute-phase reactants, C-reactive protein and serumamyloid A protein, were elevated in most of their patients witha diagnosis of unstable angina (based on the initial absenceof elevated cardiac-enzyme levels), including those who subsequentlyproved to have had a myocardial infarction. The patients withelevated levels of acute-phase reactants, which reflect thestimulation of hepatic production by circulating inflammatorymediators such as cytokines, had a less favorable . . . [Full Text of this Article]

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