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Previous Volume 332:58-59 January 5, 1995 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Achondroplasia, the most common form of dwarfism, is inherited as an autosomal dominant trait with complete penetrance. With an estimated frequency of between 1 per 15,000 and 1 per 40,000 live births, it is one of the more common mendelian disorders. Although the severity of the medical complications associated with achondroplasia is variable, the physical and radiographic features of the disorder (short limbs with a normal trunk) are remarkably consistent. Homozygous achondroplasia (occurring in one quarter of the offspring of two parents with achondroplasia) is inevitably fatal in the first year or two of life.

Both people with achondroplasia and . . . [Full Text of this Article]

References

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• Ben-Zvi, T., Yayon, A., Gertler, A., Monsonego-Ornan, E. (2006). Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling. J. Cell Sci. 119: 380-387 [Abstract] [Full Text]  
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• Korenberg, J. R., Rimoin, D. L. (1995). Medical Genetics. JAMA 273: 1692-1693 [Abstract]