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Previous Volume 332:642-645 March 9, 1995 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The use of colchicine is limited by its toxicity,¹ and colchicine overdose is associated with a high mortality rate. Patients with early hemodynamic collapse due to colchicine overdose have particularly poor prognoses,^2,3 and there has been no effective treatment for this complication of severe colchicine intoxication.⁴

Colchicine binds reversibly to tubulin,⁵ and colchicine-specific antibodies have been shown to restore the activity of tubulin in vitro.^6,7 Colchicine-specific active immunization in rabbits and passive immunization in mice with substoichiometric doses of goat colchicine-specific antibodies and their Fab fragments have been shown to prevent or reverse acute colchicine poisoning.^8,9,10,11 These findings suggested that . . . [Full Text of this Article]

Case Report

Methods

Preparation of Colchicine-Specific Fab Fragments

Treatment of the Patient with Colchicine-Specific Fab Fragments

Hemodynamic Studies

Results

Discussion

Source Information

From Réanimation Toxicologique (F.J.B., P.T., C.B.), INSERM Unité 26 (A.S., J.-M.S.), and the Département de Biophysique (E.V.), Hôpital Fernand Widal, Paris; and Pasteur-Mérieux Sérums et Vaccins, Lyon, France (J.L., J.M.R.).

Address reprint requests to Dr. Baud at Réanimation Toxicologique, Hôpital Fernand Widal, Université Paris 7, 200 rue du Faubourg Saint-Denis, 75010 Paris, France.

References

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• Kallinich, T., Haffner, D., Niehues, T., Huss, K., Lainka, E., Neudorf, U., Schaefer, C., Stojanov, S., Timmann, C., Keitzer, R., Ozdogan, H., Ozen, S. (2007). Colchicine Use in Children and Adolescents With Familial Mediterranean Fever: Literature Review and Consensus Statement. Pediatrics 119: e474-e483 [Abstract] [Full Text]  
• van Heyningen, C, Watson, I D (2005). Troponin for prediction of cardiovascular collapse in acute colchicine overdose. Emerg. Med. J. 22: 599-600 [Abstract] [Full Text]  
• Terkeltaub, R. A. (2003). Gout. NEJM 349: 1647-1655 [Full Text]  
• Kumar, A., Elitok, S., Kettritz, R. (2003). Colchicum ad nauseum. Nephrol Dial Transplant 18: 2197-2198 [Full Text]  
• Maxwell, M J, Muthu, P, Pritty, P E (2002). Accidental colchicine overdose. A case report and literature review. Emerg. Med. J. 19: 265-266 [Abstract] [Full Text]  
• Guven, A. G., Bahat, E., Akman, S., Artan, R., Erol, M. (2002). Late Diagnosis of Severe Colchicine Intoxication. Pediatrics 109: 971-973 [Abstract] [Full Text]  
• Eddleston, M. (2000). Patterns and problems of deliberate self-poisoning in the developing world. QJM 93: 715-731 [Abstract] [Full Text]  
• Ball, W. J. Jr., Kasturi, R., Dey, P., Tabet, M., O'Donnell, S., Hudson, D., Fishwild, D. (1999). Isolation and Characterization of Human Monoclonal Antibodies to Digoxin. J. Immunol. 163: 2291-2298 [Abstract] [Full Text]  
• Rivière, G., Choumet, V., Saliou, B., Debray, M., Bon, C. (1998). Absorption and Elimination of Viper Venom after Antivenom Administration. J. Pharmacol. Exp. Ther. 285: 490-495 [Abstract] [Full Text]  
• Hieda, Y., Keyler, D. E., Vandevoort, J. T., Kane, J. K., Ross, C. A., Raphael, D. E., Niedbalas, R. S., Pentel, P. R. (1997). Active Immunization Alters the Plasma Nicotine Concentration in Rats. J. Pharmacol. Exp. Ther. 283: 1076-1081 [Abstract] [Full Text]  
• Bismuth, C., Borron, S. W, Baud, F. J, Taboulet, P., Scherrmann, J.-M. (1997). Immunotoxicotherapy: Successes, disappointments and hopes. Hum Exp Toxicol 16: 602-608  
• Rivière, G., Choumet, V., Audebert, F., Sabouraud, A., Debray, M., Scherrmann, J.-M., Bon, C. (1997). Effect of Antivenom on Venom Pharmacokinetics in Experimentally Envenomed Rabbits: Toward an Optimization of Antivenom Therapy. J. Pharmacol. Exp. Ther. 281: 1-8 [Abstract] [Full Text]  
• Critchley, J. A., Critchley, L. A., Yeung, E. A., Young, R. P, Young, R. J, Chan, T. Y., Goh, V. K. (1997). Granulocyte-colony stimulating factor in the treatment of colchicine poisoning. Hum Exp Toxicol 16: 229-232 [Abstract]  
• Borron, S. W, Scherrmann, J., Baud, F. J (1996). Markedly altered colchicine kinetics in a fatal intoxication: Examination of contributing factors. Hum Exp Toxicol 15: 885-890 [Abstract]