To the Editor: Gingival hyperplasia is a known complicationof cyclosporine therapy. It appears to be worsened by the concomitantadministration of nifedipine or phenytoin.
Two transplant recipients had dramatic improvements in symptomaticgingival hyperplasia after a short course of azithromycin. Thefirst patient was a 49-year-old man with chronic glomerulonephritiswho received a cadaveric renal transplant on September 16, 1987.He received immunosuppressive therapy with corticosteroids,azathioprine, and cyclosporine. An early episode of rejectionwas treated with intravenous methylprednisolone. Gingival hyperplasiawas noted on June 6, 1989. In September 1992, a further increasein the gingival tissue was noted. . . . [Full Text of this Article]
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