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Editorial
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Volume 332:886-887 March 30, 1995 Number 13
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Airway Inflammation in Cystic Fibrosis

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During the two decades that followed the identification, in 1938, of cystic fibrosis as a distinct disease,1 few patients lived past the age of five years. At that time, most patients with cystic fibrosis died of rapidly progressive pulmonary infections. Delayed diagnosis of the disease, malnutrition, and ineffective antibiotic therapy were among the most important factors contributing to the dismal prognosis for patients with this relatively common genetic disorder. The discovery of an abnormality in sweat electrolytes soon led to the development of a simple method to diagnose cystic fibrosis and, more recently, has resulted in an understanding of the . . . [Full Text of this Article]

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