In 1866, Gregor Mendel, a high-school science teacher in whatis now Brno, Czech Republic, described plant-breeding experimentsthat he had done in the garden of the monastery of St. Thomas.The paper appeared in the transactions of the Brünn NaturalHistory Society, two years before the publication of Darwin'sOrigin of Species. Neither man knew the work of the other. Indeed,Mendel's work remained unnoticed until 1900, 16 years afterhis death. William Bateson coined the word "genetics"in 1906,invented the terms "heterozygote"and "homozygote,"and wasthe first to apply Mendel's ideas to a human disease, alkaptonuria.. . . [Full Text of this Article]
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N Engl J Med 1995;
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