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Previous Volume 332:951-952 April 6, 1995 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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It has been almost exactly 100 years since William Halsted published his seminal report on the use of radical mastectomy "for the cure of cancer of the breast,"¹ and it is fitting that this issue of the Journal includes the long-term results of two randomized trials evaluating treatment for breast cancer that might be cured with mastectomy alone.^2,3 Halsted's ideas and his operation dominated our thinking about the treatment of breast cancer until approximately 25 years ago, when a major paradigmatic shift began. The premises underlying the Halsted approach were that metastases occurred by centrifugal and contiguous spread from the . . . [Full Text of this Article]

References

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This article has been cited by other articles:

• Gamel, J. W., Edwards, M. J. (1996). Parametric Models of Therapeutic Efficacy in Breast Cancer. NEJM 334: 1270-1271 [Full Text]  
• Del Mastro, L., Costantini, M., Bianco, A. R., Newman, M. D., Evans, R. A., Bonadonna, G., Valagussa, P., Henderson, I. C. (1995). Adjuvant Chemotherapy in Breast Cancer. NEJM 333: 596-597 [Full Text]