Iron is essential for all organisms from bacteria to humans;but like excessive amounts of alcohol, which is so pleasantin moderation, a surfeit of iron is fatal. The lethal effectsof iron overload can be immediate, as in an accidental or deliberateoverdose of medicinal iron, or slow, as in congenital hemochromatosisand transfusional hemosiderosis. In the slowly developing conditions the former due to hyperabsorption of iron in food andthe latter to iatrogenic, as well as, in the case of thalassemia,hyperabsorptive factors iron stores in the reticuloendothelialsystem are filled to the brim with nontoxic . . . [Full Text of this Article]
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Deferiprone in Iron Overload
Mehta J., Singhal S., Mehta B.C., Adhikari D., Hoffbrand A.V., Wonke B., Nathan D. G.
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Full Text
N Engl J Med 1995;
333:597-599, Aug 31, 1995.
Correspondence
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