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Previous Volume 332:1004-1014 April 13, 1995 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The taxanes are an important new class of anticancer agents that exert their cytotoxic effects through a unique mechanism. Paclitaxel (Taxol), the first taxane in clinical trials, is active against a broad range of cancers that are generally considered to be refractory to conventional chemotherapy. This has led to the regulatory approval of paclitaxel in the United States and many other countries for use in the palliative therapy of patients with ovarian and breast cancers resistant to chemotherapy. The challenge now is to develop strategies using paclitaxel in the initial therapy of cancers in which cure or improved survival may . . . [Full Text of this Article]

Mechanisms of Action and Resistance

Toxicity

Hypersensitivity Reactions

Hematologic Toxicity

Neurotoxicity

Cardiac Effects

Miscellaneous Toxic Effects

Clinical Pharmacology

Antitumor Activity

Ovarian Cancer

Breast Cancer

Lung Cancer

Head and Neck Cancer

Other Tumor Types

Future Directions

Source Information

From the Divisions of Pharmacology and Experimental Therapeutics (E.K.R.) and Medical Oncology (R.C.D.), Oncology Center, Johns Hopkins University School of Medicine, Baltimore.

Address reprint requests to Dr. Rowinsky at the Johns Hopkins Oncology Center, Division of Pharmacology and Experimental Therapeutics, 1-121, 600 N. Wolfe St., Baltimore, MD 21287-8934.

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• Del Bufalo, D., Di Castro, V., Biroccio, A., Varmi, M., Salani, D., Rosano, L., Trisciuoglio, D., Spinella, F., Bagnato, A. (2002). Endothelin-1 Protects Ovarian Carcinoma Cells against Paclitaxel-Induced Apoptosis: Requirement for Akt Activation. Mol. Pharmacol. 61: 524-532 [Abstract] [Full Text]  
• Auzenne, E., Donato, N. J., Li, C., Leroux, E., Price, R. E., Farquhar, D., Klostergaard, J. (2002). Superior Therapeutic Profile of Poly-L-Glutamic Acid-Paclitaxel Copolymer Compared with Taxol in Xenogeneic Compartmental Models of Human Ovarian Carcinoma. Clin. Cancer Res. 8: 573-581 [Abstract] [Full Text]  
• Kottke, T. J., Blajeski, A. L., Meng, X. W., Svingen, P. A., Ruchaud, S., Mesner, P. W. Jr., Boerner, S. A., Samejima, K., Henriquez, N. V., Chilcote, T. J., Lord, J., Salmon, M., Earnshaw, W. C., Kaufmann, S. H. (2002). Lack of Correlation between Caspase Activation and Caspase Activity Assays in Paclitaxel-treated MCF-7 Breast Cancer Cells. J. Biol. Chem. 277: 804-815 [Abstract] [Full Text]  
• Yamaguchi, H., Paranawithana, S. R., Lee, M. W., Huang, Z., Bhalla, K. N., Wang, H.-G. (2002). Epothilone B Analogue (BMS-247550)-mediated Cytotoxicity through Induction of Bax Conformational Change in Human Breast Cancer Cells. Cancer Res. 62: 466-471 [Abstract] [Full Text]  
• Sale, S., Sung, R., Shen, P., Yu, K., Wang, Y., Duran, G. E., Kim, J.-H., Fojo, T., Oefner, P. J., Sikic, B. I. (2002). Conservation of the Class I {beta}-Tubulin Gene in Human Populations and Lack of Mutations in Lung Cancers and Paclitaxel-resistant Ovarian Cancers. Molecular Cancer Therapeutics 1: 215-225 [Abstract] [Full Text]  
• He, L., Huang Yang, C.-P., Horwitz, S. B. (2001). Mutations in {beta}-Tubulin Map to Domains Involved in Regulation of Microtubule Stability in Epothilone- resistant Cell Lines. Molecular Cancer Therapeutics 1: 3-10 [Abstract] [Full Text]  
• Koshkina, N. V., Waldrep, J. C., Roberts, L. E., Golunski, E., Melton, S., Knight, V. (2001). Paclitaxel Liposome Aerosol Treatment Induces Inhibition of Pulmonary Metastases in Murine Renal Carcinoma Model. Clin. Cancer Res. 7: 3258-3262 [Abstract] [Full Text]  
• Vredenburg, M. R., Ojima, I., Veith, J., Pera, P., Kee, K., Cabral, F., Sharma, A., Kanter, P., Greco, W. R., Bernacki, R. J. (2001). Effects of Orally Active Taxanes on P-Glycoprotein Modulation and Colon and Breast Carcinoma Drug Resistance. JNCI J Natl Cancer Inst 93: 1234-1245 [Abstract] [Full Text]  
• El Sobky, R. A., Kallab, A. M., Dainer, P. M., Jillella, A. P., Lesher, J. L. Jr (2001). Successful Treatment of an Intractable Case of Hereditary Basal Cell Carcinoma Syndrome With Paclitaxel. Arch Dermatol 137: 827-828 [Full Text]  
• Kohn, E. C., Reed, E., Sarosy, G. A., Minasian, L., Bauer, K. S., Bostick-Bruton, F., Kulpa, V., Fuse, E., Tompkins, A., Noone, M., Goldspiel, B., Pluda, J., Figg, W. D., Liotta, L. A. (2001). A Phase I Trial of Carboxyamido-triazole and Paclitaxel for Relapsed Solid Tumors: Potential Efficacy of the Combination and Demonstration of Pharmacokinetic Interaction. Clin. Cancer Res. 7: 1600-1609 [Abstract] [Full Text]  
• Heldman, A. W., Cheng, L., Jenkins, G. M., Heller, P. F., Kim, D.-W., Ware, M. Jr, Nater, C., Hruban, R. H., Rezai, B., Abella, B. S., Bunge, K. E., Kinsella, J. L., Sollott, S. J., Lakatta, E. G., Brinker, J. A., Hunter, W. L., Froehlich, J. P. (2001). Paclitaxel Stent Coating Inhibits Neointimal Hyperplasia at 4 Weeks in a Porcine Model of Coronary Restenosis. Circulation 103: 2289-2295 [Abstract] [Full Text]  
• Hidalgo, M., Aylesworth, C., Hammond, L. A., Britten, C. D., Weiss, G., Stephenson, J. Jr, Schwartz, G., Patnaik, A., Smith, L., Molpus, K., Felton, S., Gupta, E., Ferrante, K. J., Tortora, A., Sonnichsen, D. S., Skillings, J., Rowinsky, E. K. (2001). Phase I and Pharmacokinetic Study of BMS-184476, a Taxane With Greater Potency and Solubility Than Paclitaxel. JCO 19: 2493-2503 [Abstract] [Full Text]  
• Kojima, T., Kokai, Y., Chiba, H., Osanai, M., Kuwahara, K., Mori, M., Mochizuki, Y., Sawada, N. (2001). Occludin and Claudin-1 Concentrate in the Midbody of Immortalized Mouse Hepatocytes During Cell Division. J. Histochem. Cytochem. 49: 333-340 [Abstract] [Full Text]  
• Wong, P., Leung, A. N., Berry, G. J., Atkins, K. A., Montoya, J. G., Ruoss, S. J., Stockdale, F. E. (2001). Paclitaxel-Induced Hypersensitivity Pneumonitis: Radiographic and CT Findings. Am. J. Roentgenol. 176: 718-720 [Full Text]  
• Drachman, D. E., Edelman, E. R., Seifert, P., Groothuis, A. R., Bornstein, D. A., Kamath, K. R., Palasis, M., Yang, D., Nott, S. H., Rogers, C. (2000). Neointimal thickening after stent delivery of paclitaxel: change in composition and arrest of growth over six months. J Am Coll Cardiol 36: 2325-2332 [Abstract] [Full Text]  
• Symmans, W. F., Volm, M. D., Shapiro, R. L., Perkins, A. B., Kim, A. Y., Demaria, S., Yee, H. T., McMullen, H., Oratz, R., Klein, P., Formenti, S. C., Muggia, F. (2000). Paclitaxel-induced Apoptosis and Mitotic Arrest Assessed by Serial Fine-Needle Aspiration: Implications for Early Prediction of Breast Cancer Response to Neoadjuvant Treatment. Clin. Cancer Res. 6: 4610-4617 [Abstract] [Full Text]