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Previous Volume 332:1077-1082 April 20, 1995 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Coccidioidomycosis has been recognized as a distinct disease since 1892 and as a fungal infection since 1900. A recent epidemic of coccidioidomycosis in California¹ and the possibility of this infection's occurrence in association with human immunodeficiency virus (HIV) infection² have renewed interest in the disease.

The fungus Coccidioides immitis lives in soil (Figure 1). The infectious particle is the arthroconidium (arthrospore). When arthroconidia become airborne, they can establish new sites in the soil. The fungus undergoes an alternative form of development when inhaled by a potential host. In the United States, accidental inhalation of airborne arthroconidia causes an . . . [Full Text of this Article]

Epidemiology

Acute Infection

The Host Response

Chronic Forms of Infection

Diagnosis

Especially Susceptible Groups

Therapy

Source Information

From the Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose; the Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford; and the California Institute for Medical Research, San Jose — all in California.

Address reprint requests to Dr. Stevens at the Santa Clara Valley Medical Center, 751 S. Bascom Ave., San Jose, CA 95128-2699.

References

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• Baden, L. R., Digumarthy, S. R., Guimaraes, A. S.R., Branda, J. A. (2009). Case 35-2009 -- A 60-Year-Old Male Renal-Transplant Recipient with Renal Insufficiency, Diabetic Ketoacidosis, and Mental-Status Changes. NEJM 361: 1980-1989 [Full Text]  
• Graupmann-Kuzma, A., Valentine, B. A., Shubitz, L. F., Dial, S. M., Watrous, B., Tornquist, S. J. (2008). Coccidioidomycosis in Dogs and Cats: A Review. Journal of the American Animal Hospital Association 44: 226-235 [Abstract] [Full Text]  
• CAPONE, D, MARCHIORI, E, WANKE, B, DANTAS, K E, CAVALCANTI, M A S, DEUS FILHO, A, ESCUISSATO, D L, WARSZAWIAK, D (2008). Acute pulmonary coccidioidomycosis: CT findings from 15 patients. Br. J. Radiol. 81: 721-724 [Abstract] [Full Text]  
• Wilde, G. E., Emery, C., Lally, J. F. (2008). Radiological Reasoning: Miliary Disease, Vertebral Osteomyelitis, and Soft-Tissue Abscesses. Am. J. Roentgenol. 190: S11-S17 [Abstract] [Full Text]  
• Martin-Davila, P., Fortun, J., Lopez-Velez, R., Norman, F., Montes de Oca, M., Zamarron, P., Gonzalez, M. I., Moreno, A., Pumarola, T., Garrido, G., Candela, A., Moreno, S. (2008). Transmission of Tropical and Geographically Restricted Infections during Solid-Organ Transplantation. Clin. Microbiol. Rev. 21: 60-96 [Abstract] [Full Text]  
• Ah-Fong, A. M. V., Xiang, Q., Judelson, H. S. (2007). Architecture of the Sporulation-Specific Cdc14 Promoter from the Oomycete Phytophthora infestans. Eukaryot Cell 6: 2222-2230 [Abstract] [Full Text]  
• Risbano, M. G., Groshong, S. D., Schwarz, M. I. (2007). Lung Nodules in a Woman With a History of Breast Cancer. Chest 132: 1697-1701 [Full Text]  
• Kamberi, P., Sobel, R. A., Clemons, K. V., Waldvogel, A., Striebel, J. M., Williams, P. L., Stevens, D. A. (2007). Comparison of Itraconazole and Fluconazole Treatments in a Murine Model of Coccidioidal Meningitis. Antimicrob. Agents Chemother. 51: 998-1003 [Abstract] [Full Text]  
• Spinello, I. M., Johnson, R. H. (2006). A 19-year-old pregnant woman with a skin lesion and respiratory failure.. Chest 130: 611-615 [Full Text]  
• Sandoval, J. J., Shank, J. R., Morgan, S. J., Agudelo, J. F., Price, C. S. (2006). Midfoot Coccidioidal Osteomyelitis. A Case Report and Review of the Literature. JBJS 88: 861-865 [Full Text]  
• Kellner, E. M., Orsborn, K. I., Siegel, E. M., Mandel, M. A., Orbach, M. J., Galgiani, J. N. (2005). Coccidioides posadasii Contains a Single 1,3-{beta}-Glucan Synthase Gene That Appears To Be Essential for Growth. Eukaryot Cell 4: 111-120 [Abstract] [Full Text]  
• Kolivras, K. N., Comrie, n. C. (2004). Climate and infectious disease in the southwestern United States. Progress in Physical Geography 28: 387-398 [Abstract]  
• Miller, M. B., Hendren, R., Gilligan, P. H. (2004). Posttransplantation Disseminated Coccidioidomycosis Acquired from Donor Lungs. J. Clin. Microbiol. 42: 2347-2349 [Abstract] [Full Text]  
• (2004). Multiple Hyperkeratotic Plaques and Lower Extremity Weakness--Diagnosis. Arch Dermatol 140: 609-614 [Full Text]  
• Tomic, R., Pelaez, A., Klass, C., Silverboard, H. (2003). Pulmonary Artery Aneurysm Caused by Coccidioidomycosis. Chest Meeting 124: 318S-319 [Abstract] [Full Text]  
• Komotar, J R, Clatterbuck, R E (2003). Coccidioidomycosis of the brain, mimicking en plaque meningioma. J. Neurol. Neurosurg. Psychiatry 74: 806-806 [Full Text]  
• Ryu, J. H., Swensen, S. J. (2003). Cystic and Cavitary Lung Diseases: Focal and Diffuse. Mayo Clin Proc. 78: 744-752 [Abstract]  
• Richards, J. O., Ampel, N. M., Lake, D. F. (2002). Reversal of Coccidioidal Anergy In Vitro by Dendritic Cells from Patients with Disseminated Coccidioidomycosis. J. Immunol. 169: 2020-2025 [Abstract] [Full Text]  
• Clemons, K. V., Sobel, R. A., Williams, P. L., Pappagianis, D., Stevens, D. A. (2002). Efficacy of Intravenous Liposomal Amphotericin B (AmBisome) against Coccidioidal Meningitis in Rabbits. Antimicrob. Agents Chemother. 46: 2420-2426 [Abstract] [Full Text]  
• Peng, T., Shubitz, L., Simons, J., Perrill, R., Orsborn, K. I., Galgiani, J. N. (2002). Localization within a Proline-Rich Antigen (Ag2/PRA) of Protective Antigenicity against Infection with Coccidioides immitis in Mice. Infect. Immun. 70: 3330-3335 [Abstract] [Full Text]  
• Jiang, C., Magee, D. M., Ivey, F. D., Cox, R. A. (2002). Role of Signal Sequence in Vaccine-Induced Protection against Experimental Coccidioidomycosis. Infect. Immun. 70: 3539-3545 [Abstract] [Full Text]  
• Shubitz, L., Peng, T., Perrill, R., Simons, J., Orsborn, K., Galgiani, J. N (2002). Protection of Mice against Coccidioides immitis Intranasal Infection by Vaccination with Recombinant Antigen 2/PRA. Infect. Immun. 70: 3287-3289 [Abstract] [Full Text]  
• Galgiani, J. N., Catanzaro, A., Cloud, G. A., Johnson, R. H., Williams, P. L., Mirels, L. F., Nassar, F., Lutz, J. E., Stevens, D. A., Sharkey, P. K., Singh, V. R., Larsen, R. A., Delgado, K. L., Flanigan, C., Rinaldi, M. G. (2000). Comparison of Oral Fluconazole and Itraconazole for Progressive, Nonmeningeal Coccidioidomycosis: A Randomized, Double-Blind Trial. ANN INTERN MED 133: 676-686 [Abstract] [Full Text]  
• Sorensen, K. N., Sobel, R. A., Clemons, K. V., Pappagianis, D., Stevens, D. A., Williams, P. L. (2000). Comparison of Fluconazole and Itraconazole in a Rabbit Model of Coccidioidal Meningitis. Antimicrob. Agents Chemother. 44: 1512-1517 [Abstract] [Full Text]  
• Jiang, C., Magee, D. M., Cox, R. A. (1999). Coadministration of Interleukin 12 Expression Vector with Antigen 2 cDNA Enhances Induction of Protective Immunity against Coccidioides immitis. Infect. Immun. 67: 5848-5853 [Abstract] [Full Text]  
• Spivack, S. D., Mark, E. J. (1999). Case 21-1999- A 69-Year-Old Man with Exposure to Talc and a Pulmonary Mass. NEJM 341: 182-190 [Full Text]  
• Abuodeh, R. O., Shubitz, L. F., Siegel, E., Snyder, S., Peng, T., Orsborn, K. I., Brummer, E., Stevens, D. A., Galgiani, J. N. (1999). Resistance to Coccidioides immitis in Mice after Immunization with Recombinant Protein or a DNA Vaccine of a Proline-Rich Antigen. Infect. Immun. 67: 2935-2940 [Abstract] [Full Text]  
• Jiang, C., Magee, D. M., Cox, R. A. (1999). Construction of a Single-Chain Interleukin-12-Expressing Retroviral Vector and Its Application in Cytokine Gene Therapy against Experimental Coccidioidomycosis. Infect. Immun. 67: 2996-3001 [Abstract] [Full Text]  
• Lortholary, O., Denning, D. W., Dupont, B. (1999). Endemic mycoses: a treatment update. J Antimicrob Chemother 43: 321-331 [Abstract] [Full Text]  
• Galgiani, J. N. (1999). Coccidioidomycosis: A Regional Disease of National Importance: Rethinking Approaches for Control. ANN INTERN MED 130: 293-300 [Abstract] [Full Text]  
• Jiang, C., Magee, D. M., Quitugua, T. N., Cox, R. A. (1999). Genetic Vaccination against Coccidioides immitis: Comparison of Vaccine Efficacy of Recombinant Antigen 2 and Antigen 2 cDNA. Infect. Immun. 67: 630-635 [Abstract] [Full Text]  
• Williams, F M K, Markides, V, Edgeworth, J, Williams, A J (1998). Reactivation of coccidioidomycosis in a fit American visitor. Thorax 53: 811-812 [Abstract] [Full Text]  
• Cunningham, E. T. Jr, Seiff, S. R., Berger, T. G., Lizotte, P. E., Howes, E. L. Jr, Horton, J. C. (1998). Intraocular Coccidioidomycosis Diagnosed by Skin Biopsy. Arch Ophthalmol 116: 674-677 [Abstract] [Full Text]  
• Marrero, G. M., Glinick, S. E., Wilkel, C. S., Passero, M. A. (1998). Nonhealing Neck Ulcers. Arch Dermatol 134: 365-370 [Full Text]  
• Smilack, J. D., Argueta, R. (1998). Coccidioidal Infection of the Thyroid. Arch Intern Med 158: 89-92 [Abstract] [Full Text]  
• Scharfstein, J. A., Paltiel, A. D., Freedberg, K. A. (1997). The Cost-Effectiveness of Fluconazole Prophylaxis against Primary Systemic Fungal Infections in AIDS Patients. Med Decis Making 17: 373-381 [Abstract]  
• Schneider, E., Hajjeh, R. A., Spiegel, R. A., Jibson, R. W., Harp, E. L., Marshall, G. A., Gunn, R. A., McNeil, M. M., Pinner, R. W., Baron, R. C., Burger, R. C., Hutwagner, L. C., Crump, C., Kaufman, L., Reef, S. E., Feldman, G. M., Pappagianis, D., Werner, S. B. (1997). A Coccidioidomycosis Outbreak Following the Northridge, Calif, Earthquake. JAMA 277: 904-908 [Abstract]