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Previous Volume 332:1091-1092 April 20, 1995 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In this issue of the Journal, Verdonck et al.¹ report on a study that, as they planned it, was barely large enough to detect a massive advantage for a controversial and expensive therapy. Moreover, the way they calculated the size of their sample was too forgiving: it presupposed a one-sided test of significance, which ordinarily would not be acceptable in these pages. Yet the study does appear here, and it provides evidence strong enough to guide therapeutic decisions. What went right?

Verdonck et al. studied patients with non-Hodgkin's lymphoma who had partial responses to three cycles of CHOP therapy (cyclophosphamide, . . . [Full Text of this Article]

References

Related Letters:

Bone Marrow Transplantation versus Chemotherapy in Non-Hodgkin's Lymphoma
Seymour J. F., Flecknoe-Brown S., Mross K., Burke H. B., Nimer S. D., Zelenetz A., Portlock C., Finckh W., Fielding A. K., Pearce R. M., Goldstone A. H., Selwyn M. R., Verdonck L. F., van Putten W. L.J., Hagenbeek A., Walker A. M.
Extract | Full Text  
N Engl J Med 1995; 333:727-730, Sep 14, 1995. Correspondence

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