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Previous Volume 332:1210-1217 May 4, 1995 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Diabetes mellitus is a chronic disease characterized by hyperglycemia and by complications that include microvascular disease of the eye and kidney and a variety of clinical neuropathies.¹ Although diabetes is also associated with premature macrovascular disease, this review is limited to a discussion of retinopathy, nephropathy, and neuropathy. The pathophysiology of these complications of diabetes was recently reviewed in the Journal.¹

The specific association of microvascular disease and neuropathy with diabetes and the relation of the two complications to the duration of diabetes suggest that they are linked to hyperglycemia or a concomitant metabolic abnormality. The Diabetes Control and Complications . . . [Full Text of this Article]

General Prevention

Intensive Treatment

Interference with the Basic Pathophysiologic Mechanisms of Complications

Retinopathy

Prevention

Detection

Treatment

Nephropathy

Prevention

            Intensive Management

            Angiotensin-Converting–Enzyme Inhibition

            Aldose Reductase Inhibition

Detection

Treatment

            Antihypertensive Therapy

            Protein Restriction

Neuropathy

Prevention

Treatment

            Symptomatic Peripheral Neuropathy

            Autonomic Neuropathy

Future Perspectives

Source Information

From the Regenstrief Institute for Health Care, Richard Roudebush Veterans Affairs Medical Center (C.M.C.), and the Department of Medicine (C.M.C., D.A.L.), Indiana University School of Medicine, Indianapolis.

Address reprint requests to Dr. Clark at the Regenstrief Institute for Health Care, 1001 W. 10th St., Indianapolis, IN 46202.

References

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