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Previous Volume 332:1238-1239 May 4, 1995 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Although the review of childhood brain tumors by Pollack (Dec. 1 issue)¹ is excellent, it is based on the assumption that "the initial step in treatment is surgery to establish the histologic diagnosis and to reduce the tumor burden." The assumption that a histologic diagnosis is correct, predicts biologic behavior, and is a determinant of outcome may not be true for childhood brain tumors.

Histologic features are not necessarily reliably and reproducibly identified by teams of observers² and are not necessarily assembled reliably into diagnostic categories.³ The objective criteria by which histologic features are used to make . . . [Full Text of this Article]

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