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Previous Volume 332:1280-1284 May 11, 1995 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The study of Streptococcus pneumoniae has led to many insights into the pathogenesis of bacterial infections. The importance of the polysaccharide capsule of the organism in determining its virulence was indicated by studies of the protective role of anticapsular antibodies.^1,2,3 Of comparable importance was the observation that noncapsulated pneumococci caused progressive disease in rabbits with agranulocytosis, demonstrating thereby the pathogenic properties of the pneumococcal soma.⁴ Investigation of the pathologic events in pneumococcal infection led to the discovery of DNA,^2,3 the development of the first bacterial polysaccharide vaccine,⁵ and insights into the mechanism of action of penicillin,⁶ antibiotic tolerance,⁷ the complex . . . [Full Text of this Article]

Surface Components of Pneumococci

Capsule

Cell Wall

Surface Proteins

Biology of Pneumococcal Infection

Conclusions

Source Information

From the Laboratory of Molecular Infectious Diseases, Rockefeller University, New York (E.I.T., H.R.M.), and the Department of Molecular and Cellular Engineering, University of Pennsylvania, Philadelphia (R.A.).

Address reprint requests to Dr. Tuomanen at the Laboratory of Molecular Infectious Diseases, Rockefeller University, 1230 York Ave., New York, NY 10021.

References

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