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Correspondence
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Volume 332:128 January 12, 1995 Number 2
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Expression of P Antigen in Parvovirus B19–Infected Bone Marrow

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To the Editor: Parvovirus B19 causes erythema infectiosum,1 transient aplastic crisis,2 hydrops fetalis,3 and persistent infection in immunocompromised patients.4,5 Replication of parvovirus B19 has been demonstrated only in human erythroid progenitor cells, a tropism explained by the recent discovery of the cellular receptor of B19.6 The virus binds to P antigen of the P system blood group, as demonstrated by in vitro hemagglutination. Parvovirus B19 does not agglutinate erythrocytes from persons with the P1k or p phenotypes,6 and bone marrow from persons lacking P antigen is naturally resistant to parvovirus B19 infection, as Brown et al. have shown (April 28 . . . [Full Text of this Article]

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