FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 332:1372-1374 May 18, 1995 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Fifty years ago this spring, a conversation between an eminent clinical investigator and an extraordinarily imaginative physical chemist led to the insight that introduced the era of molecular medicine. Although their recollections of the encounter differed slightly, this meeting of Drs. William B. Castle and Linus Pauling soon led to the identification, by Pauling's laboratory, of an abnormal hemoglobin molecule in the erythrocytes of patients with sickle cell anemia. In the subsequent decades, the techniques of genetics, biochemistry, and cell biology have all contributed to the detailed elucidation of the molecular and cellular pathophysiology of this inherited disease.

Nevertheless, a . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Schechter, A. N., Rodgers, G. P., Adams-Graves, P., Heltsley, C., Deitcher, S. (1996). Hydroxyurea in Sickle Cell Disease. NEJM 334: 333-334 [Full Text]  
• Ho, P. T.C., Murgo, A. J., Silver, R. T., Charache, S., Dover, G. J., Moore, R. D., Terrin, M. L. (1995). Hydroxyurea and Sickle Cell Crisis. NEJM 333: 1008-1009 [Full Text]