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Previous Volume 332:1381-1384 May 18, 1995 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Hajjar, K. A. Related Article by Greengard, J. S. Related Article by Greengard, J. S. PubMed Citation

To the Editor: Greengard et al. (Dec. 8 issue)¹ describe siblings, from a symptomatic family, who were homozygous for the arginine glutamine mutation at position 506 in the factor V gene. On the basis of this report and others,^2,3,4 one can estimate that there are hundreds of thousands of homozygotes in Europe and the United States. Many of them probably come from families in which the heterozygous state is asymptomatic, since the mutation is very common in the general population.^1,2,3,4 At present, it is not known whether homozygous members of such families have an increased risk of thrombosis.

We examined . . . [Full Text of this Article]

References

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• Rosing, J., Hoekema, L., Nicolaes, G. A. F., D. Thomassen, M. C. L. G., Hemker, H. C., Varadi, K., Schwarz, H. P., Tans, G. (1995). Effects of Protein S and Factor Xa on Peptide Bond Cleavages during Inactivation of Factor Va and Factor Va[IMAGE] by Activated Protein C. J. Biol. Chem. 270: 27852-27858 [Abstract] [Full Text]