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Volume 332:1518-1520 June 1, 1995 Number 22
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Gastrointestinal Polyposis and Nonpolyposis Syndromes

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by Rustgi, A. K.
To the Editor: The review of gastrointestinal polyposis and nonpolyposis syndromes by Rustgi (Dec. 22 issue)1 inappropriately distinguishes the hereditary flat adenoma syndrome from attenuated adenomatous polyposis coli (and in doing so perpetuates the misnomer "hereditary flat adenoma syndrome"). These are, in fact, two names for the same syndrome. Attenuated adenomatous polyposis coli is characterized clinically by many, but usually fewer than 100, colonic adenomatous polyps, increased risk of colon cancer, and an age of onset of colon cancer that is between the age of onset of classic polyposis coli and that of sporadic colon cancer. Genetic analysis of a . . . [Full Text of this Article]

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