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The Nuremburg Trial and the annunciation of the Nuremburg Code in 1947 were watershed events in the history of the ethics of human experimentation. Although some of the judges who issued the judgment at Nuremburg were Americans, the period from the 1940s to the 1970s continued to reveal examples of the use and abuse of vulnerable human subjects in biomedical research in the United States. Experiments were often conducted under duress and without consent on military personnel, prisoners, children, the incompetent, the elderly, and the dying. Formal regulations protecting human subjects participating in biomedical and behavioral research were not promulgated
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