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Editorial
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Volume 332:1575-1576 June 8, 1995 Number 23
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The Clinical Importance of the Urinary Excretion of Aquaporin-2

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The movement of water across the cell membranes of an organism is of central importance in many functions. The notion that the permeability of some tissues to water is too great to be accounted for by lipid-mediated diffusion has been central to the development of the concept of channel-mediated water transport. Despite the general acceptance of the existence of water-channel proteins, their molecular identification has long remained elusive. The first water-channel protein, originally known as CHIP28 (an acronym for channel-forming integral membrane protein of 28 kd), was discovered during studies of erythrocyte blood-group proteins.1 Its expression in xenopus oocytes results . . . [Full Text of this Article]

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