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Previous Volume 332:1584-1585 June 8, 1995 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Recombinant interferon beta-1b (Betaseron) was licensed in 1993 to reduce exacerbations of multiple sclerosis. Approval of the drug was greeted enthusiastically, despite a modest 30 percent reduction in relapses and side effects that include local inflammatory reactions and a flulike syndrome.¹ We report the occurrence of severe necrotizing cutaneous reactions in a 38-year-old woman with an eight-year history of multiple sclerosis. She self-injected the standard dose of recombinant interferon beta-1b (9 million units) subcutaneously on alternate days.

Erythematous patches appeared at the injection sites on both thighs during the third month of treatment. These areas became violaceous, . . . [Full Text of this Article]

References

Related Letters:

More on Interferon-Induced Cutaneous Necrosis
Shinohara K., Trautinger F., Knobler R. M., Sheremata W. A., Taylor J. R., Elgart G. W.
Extract | Full Text  
N Engl J Med 1995; 333:1222-1224, Nov 2, 1995. Correspondence

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• Koontz, D., Alshekhlee, A. (2007). Letter to the Editor: Embolia cutis medicamentosa following interferon beta injection. Mult Scler 13: 1203-1204  
• Casoni, F., Merelli, E., Bedin, R., Martella, A., Cesinaro, A., Bertolotto, A. (2003). Necrotizing skin lesions and NA Bs development in a multiple sclerosis patient treated with IFN{beta} 1b. Mult Scler 9: 420-423 [Abstract]  
• CREANGE, A., LEFAUCHEUR, J.-P. (2000). Focal neuropathy associated with cutaneous necrosis at the site of interferon-beta injection for multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 68: 395-395 [Full Text]  
• RADZIWILL, A. J, COURVOISIER, S. (1999). Severe necrotising cutaneous lesions complicating treatment with interferon beta -1a. J. Neurol. Neurosurg. Psychiatry 67: 115-115 [Full Text]  
• Gaines, A. R., Varricchio, F. (1998). Interferon beta-1b injection site reactions and necroses. Mult Scler 4: 70-73 [Abstract]  
• Shinohara, K., Trautinger, F., Knobler, R. M., Sheremata, W. A., Taylor, J. R., Elgart, G. W. (1995). More on Interferon-Induced Cutaneous Necrosis. NEJM 333: 1222-1224 [Full Text]