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Previous Volume 332:1618-1630 June 15, 1995 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The childhood leukemias are a study in contrasts. Acute lymphoblastic leukemia (ALL) is diagnosed in approximately 2000 children in the United States each year, whereas acute myeloid leukemia (AML) is diagnosed in only about 500 children, and chronic myeloid leukemia (CML) in fewer than 100. Chronic lymphocytic leukemia (CLL), one of the most common leukemias in adults, seldom occurs in children. Current chemotherapeutic regimens cure as many as 70 percent of children with ALL (Figure 1)^1,2,3,4 but only 30 to 40 percent of those with AML,^5,6,7,8,9,10 and they are ineffective against CML without allogeneic bone marrow transplantation.¹¹

View larger version (3K): [in this window] [in a new window]   Figure 1. Kaplan–Meier . . . [Full Text of this Article]

 
Risk Factors

Pathological Features and Cell Classification

Morphologic and Cytochemical Characteristics

Immunophenotype

Cellular and Molecular Genetic Features

Evolving Areas in Clinical Management

Risk-Specific Therapy

            Acute Lymphoblastic Leukemia

            Acute Myeloid Leukemia

            Chronic Myeloid Leukemia

Treatment of Subclinical Leukemia in the Central Nervous System

Cell Growth and Drug-Sensitivity Testing

Detection of Minimal Residual Leukemia

Late Effects

Future Considerations

Source Information

From the Departments of Hematology–Oncology and Pathology and Laboratory Medicine, St. Jude Children's Research Hospital, and the University of Tennessee, Memphis, College of Medicine — both in Memphis.

Address reprint requests to Dr. Pui at St. Jude Children's Research Hospital, 332 N. Lauderdale, P.O. Box 318, Memphis, TN 38101-0318.

References

Related Letters:

Childhood Leukemias
Landrigan P. J., Pui C.-H.
Extract | Full Text  
N Engl J Med 1995; 333:1286-1287, Nov 9, 1995. Correspondence

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