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Correspondence
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Volume 332:1653-1654 June 15, 1995 Number 24
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Antiemetic Properties of Granisetron

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 by The Italian Group for Antiemetic Research
To the Editor: The article on the use of granisetron and dexamethasone to prevent chemotherapy-induced nausea and vomiting (Jan. 5 issue)1 does not appear to be relevant to current practice in the United States. The study group used 3 mg of granisetron, which is triple the dose recommended to provide an effect equivalent to that of 32 mg of ondansetron. Furthermore, a simple economic analysis makes it clear that this dose would be exceedingly unappealing to any purchaser of health care. At a rock-bottom cost of $135 per milligram of granisetron, each treatment would cost approximately $400. Since the study . . . [Full Text of this Article]

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