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Correspondence
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Volume 332:1719 June 22, 1995 Number 25
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Human Immunodeficiency Virus

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 by Phillips, D. M.
To the Editor: The caption to the transmission electron microphotograph of the human immunodeficiency virus (HIV) that shows HIV-1 budding from a cell (Jan. 26 issue)1 states that during the budding process, "The membrane proteins of the cell are left behind when the virus buds off." We have recently shown that cellular proteins (HLA class I and class II proteins) are incorporated into the intact virus.2 In fact, the concentrations of these cellular proteins may be even higher than those of the viral-envelope glycoproteins. Orentas and Hildreth,3 using solid-phase capture techniques, have identified several other virus-associated cellular proteins, including CD71, . . . [Full Text of this Article]

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