FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 332:1749-1751 June 29, 1995 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Human T-cell lymphotropic virus type I (HTLV-I)¹ is the etiologic agent of adult T-cell leukemia-lymphoma.² The serum of patients with this disease contains antibodies to HTLV-I,³ and there is monoclonal integration of HTLV-I proviruses in the malignant cells.⁴ The principal clinical features of adult T-cell leukemia-lymphoma⁵ are lymphadenopathy, hepatosplenomegaly, skin lesions, and hypercalcemia. Compromise of the immune system can allow opportunistic infection. The blood contains abnormal lymphocytes with characteristic indented or convoluted nuclei (``flower cells''). These malignant lymphocytes are activated CD4-positive T cells with increased expression of the alpha chain of the interleukin-2 receptor.

Four different clinical subtypes of adult . . . [Full Text of this Article]

Case Reports

Patient 1

Patient 2

Patient 3

Patient 4

Patient 5

Discussion

Source Information

From the Departments of Clinical Hematology (O.H., A.B.-V.) and Biologic Hematology (E.M.), Hopital Necker, Paris; the Departments of Clinical Hematology (D.B., F.D.) and Dermatology (N.F.), Hopital Cochin, Paris; the Department of Retroviruses, Institut Pasteur, Paris (A.G.); the Department of Clinical Hematology, Hopital Beaujon, Clichy (P.T.); the Department of Clinical Hematology, Hopital de la Pitie, Paris (V.L.); and the Department of Clinical Hematology, Hotel-Dieu, Paris (B.R., A.B.) -- all in France.

Address reprint requests to Dr. Hermine at the Service d'Hematologie Adulte, Hopital Necker, 149 rue de Sevres, 75743 Paris CEDEX 15, France.

References

This article has been cited by other articles:

• Balestrieri, E., Matteucci, C., Ascolani, A., Piperno, A., Romeo, R., Romeo, G., Chiacchio, U., Mastino, A., Macchi, B. (2008). Effect of Phosphonated Carbocyclic 2'-Oxa-3'-Aza-Nucleoside on Human T-Cell Leukemia Virus Type 1 Infection In Vitro. Antimicrob. Agents Chemother. 52: 54-64 [Abstract] [Full Text]  
• Matutes, E (2007). Adult T-cell leukaemia/lymphoma. J. Clin. Pathol. 60: 1373-1377 [Abstract] [Full Text]  
• Dbaibo, G. S., Kfoury, Y., Darwiche, N., Panjarian, S., Kozhaya, L., Nasr, R., Abdallah, M., Hermine, O., El-Sabban, M., de The, H., Bazarbachi, A. (2007). Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity. haematol 92: 753-762 [Abstract] [Full Text]  
• Ramos, J. C., Ruiz, P. Jr, Ratner, L., Reis, I. M., Brites, C., Pedroso, C., Byrne, G. E. Jr, Toomey, N. L., Andela, V., Harhaj, E. W., Lossos, I. S., Harrington, W. J. Jr (2007). IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma. Blood 109: 3060-3068 [Abstract] [Full Text]  
• Brown, M., Bellon, M., Nicot, C. (2007). Emodin and DHA potently increase arsenic trioxide interferon-{alpha}-induced cell death of HTLV-I-transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1. Blood 109: 1653-1659 [Abstract] [Full Text]  
• Datta, A., Bellon, M., Sinha-Datta, U., Bazarbachi, A., Lepelletier, Y., Canioni, D., Waldmann, T. A., Hermine, O., Nicot, C. (2006). Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence. Blood 108: 1021-1029 [Abstract] [Full Text]  
• Richardson, S., Budgin, J. B., Junkins-Hopkins, J. M., Vittorio, C. C., Lee, J., Miller, W. T. Jr, Rook, A. H., Kim, E. J. (2005). Low-Dose Bexarotene and Low-Dose Interferon Alfa-2b for Adult T-Cell Leukemia/Lymphoma Associated With Human T-Lymphotropic Virus 1. Arch Dermatol 141: 301-304 [Full Text]  
• Sinha-Datta, U., Horikawa, I., Michishita, E., Datta, A., Sigler-Nicot, J. C., Brown, M., Kazanji, M., Barrett, J. C., Nicot, C. (2004). Transcriptional activation of hTERT through the NF-{kappa}B pathway in HTLV-I-transformed cells. Blood 104: 2523-2531 [Abstract] [Full Text]  
• Tobinai, K., Hotta, T. (2004). Clinical Trials for Malignant Lymphoma in Japan. Jpn J Clin Oncol 34: 369-378 [Abstract] [Full Text]  
• Moura, I. C., Lepelletier, Y., Arnulf, B., England, P., Baude, C., Beaumont, C., Bazarbachi, A., Benhamou, M., Monteiro, R. C., Hermine, O. (2004). A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients. Blood 103: 1838-1845 [Abstract] [Full Text]  
• Macchi, B., Balestrieri, E., Mastino, A. (2003). Effects of nucleoside-based antiretroviral chemotherapy on human T cell leukaemia/lymphotropic virus type 1 (HTLV-1) infection in vitro. J Antimicrob Chemother 51: 1327-1330 [Full Text]  
• Nasr, R., Rosenwald, A., El-Sabban, M. E., Arnulf, B., Zalloua, P., Lepelletier, Y., Bex, F., Hermine, O., Staudt, L., de The, H., Bazarbachi, A. (2003). Arsenic/interferon specifically reverses 2 distinct gene networks critical for the survival of HTLV-1-infected leukemic cells. Blood 101: 4576-4582 [Abstract] [Full Text]  
• Ghosh, S. K., Wood, C., Boise, L. H., Mian, A. M., Deyev, V. V., Feuer, G., Toomey, N. L., Shank, N. C., Cabral, L., Barber, G. N., Harrington, W. J. Jr (2003). Potentiation of TRAIL-induced apoptosis in primary effusion lymphoma through azidothymidine-mediated inhibition of NF-kappa B. Blood 101: 2321-2327 [Abstract] [Full Text]  
• Arnulf, B., Villemain, A., Nicot, C., Mordelet, E., Charneau, P., Kersual, J., Zermati, Y., Mauviel, A., Bazarbachi, A., Hermine, O. (2002). Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis. Blood 100: 4129-4138 [Abstract] [Full Text]  
• El-Sabban, M. E., Merhi, R. A., Haidar, H. A., Arnulf, B., Khoury, H., Basbous, J., Nijmeh, J., de The, H., Hermine, O., Bazarbachi, A. (2002). Human T-cell lymphotropic virus type 1-transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells. Blood 99: 3383-3389 [Abstract] [Full Text]  
• Mahieux, R., Pise-Masison, C., Gessain, A., Brady, John. N., Olivier, R., Perret, E., Misteli, T., Nicot, C. (2001). Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2-infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage. Blood 98: 3762-3769 [Abstract] [Full Text]  
• El-Sabban, M. E., Nasr, R., Dbaibo, G., Hermine, O., Abboushi, N., Quignon, F., Ameisen, J. C., Bex, F., de The, H., Bazarbachi, A. (2000). Arsenic-interferon-alpha -triggered apoptosis in HTLV-I transformed cells is associated with Tax down-regulation and reversal of NF-kappa B activation. Blood 96: 2849-2855 [Abstract] [Full Text]  
• Bangham, C. R M (2000). HTLV-1 infections. J. Clin. Pathol. 53: 581-586 [Abstract] [Full Text]  
• Nicot, C., Mahieux, R., Takemoto, S., Franchini, G. (2000). Bcl-XL is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples. Blood 96: 275-281 [Abstract] [Full Text]  
• Franchini, G., Ambinder, R. F., Barry, M. (2000). Viral Disease in Hematology. ASH Education Book 2000: 409-423 [Abstract] [Full Text]  
• Manns, A., Miley, W. J., Waters, D., Hanchard, B., Wharfe, G., Cranston, B., Williams, E., Blattner, W. A. (1999). Prognostic Significance of Quantitative Viral Markers in Adult T-Cell Leukemia/Lymphoma. Blood 94: 372-373 [Full Text]  
• Bazarbachi, A., El-Sabban, M. E., Nasr, R., Quignon, F., Awaraji, C., Kersual, J., Dianoux, L., Zermati, Y., Haidar, J. H., Hermine, O., de The, H. (1999). Arsenic Trioxide and Interferon-alpha Synergize to Induce Cell Cycle Arrest and Apoptosis in Human T-Cell Lymphotropic Virus Type I-Transformed Cells. Blood 93: 278-283 [Abstract] [Full Text]  
• Lau, A., Nightingale, S., Taylor, G. P., Gant, T. W., Cann, A. J. (1998). Enhanced MDR1 Gene Expression in Human T-Cell Leukemia Virus-I-Infected Patients Offers New Prospects for Therapy. Blood 91: 2467-2474 [Abstract] [Full Text]  
• Tobinai, K., Kobayashi, Y., Shimoyama, M., The Lymphoma Study Group of the Japan Clinical Onc, , Pagano, J. S., Gill, P. S., Harrington, W., Levine, A. M. (1995). Interferon Alfa and Zidovudine in Adult T-Cell Leukemia-Lymphoma. NEJM 333: 1285-1286 [Full Text]  
• Gallo, R. C. (1995). A Surprising Advance in the Treatment of Viral Leukemia. NEJM 332: 1783-1785 [Full Text]