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Previous Volume 332:1749-1751 June 29, 1995 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Human T-cell lymphotropic virus type I (HTLV-I)¹ is the etiologic agent of adult T-cell leukemia-lymphoma.² The serum of patients with this disease contains antibodies to HTLV-I,³ and there is monoclonal integration of HTLV-I proviruses in the malignant cells.⁴ The principal clinical features of adult T-cell leukemia-lymphoma⁵ are lymphadenopathy, hepatosplenomegaly, skin lesions, and hypercalcemia. Compromise of the immune system can allow opportunistic infection. The blood contains abnormal lymphocytes with characteristic indented or convoluted nuclei (``flower cells''). These malignant lymphocytes are activated CD4-positive T cells with increased expression of the alpha chain of the interleukin-2 receptor.

Four different clinical subtypes of adult . . . [Full Text of this Article]

Case Reports

Patient 1

Patient 2

Patient 3

Patient 4

Patient 5

Discussion

Source Information

From the Departments of Clinical Hematology (O.H., A.B.-V.) and Biologic Hematology (E.M.), Hopital Necker, Paris; the Departments of Clinical Hematology (D.B., F.D.) and Dermatology (N.F.), Hopital Cochin, Paris; the Department of Retroviruses, Institut Pasteur, Paris (A.G.); the Department of Clinical Hematology, Hopital Beaujon, Clichy (P.T.); the Department of Clinical Hematology, Hopital de la Pitie, Paris (V.L.); and the Department of Clinical Hematology, Hotel-Dieu, Paris (B.R., A.B.) -- all in France.

Address reprint requests to Dr. Hermine at the Service d'Hematologie Adulte, Hopital Necker, 149 rue de Sevres, 75743 Paris CEDEX 15, France.

References

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