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Previous Volume 332:318-320 February 2, 1995 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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One of the most important tools underlying the revolution in medical genetics is the ability to visualize sequence differences directly in DNA. When studied in the context of a population, these differences in DNA sequences are called polymorphisms; they may occur in coding regions (exons) or noncoding regions of genes. The ability to visualize thousands of DNA polymorphisms has made possible family studies for tracking genes of medical importance. This technique has located and identified genes for many disorders with a clear pattern of mendelian inheritance, such as cystic fibrosis, the inherited muscular dystrophies, and neurodegenerative disorders such as Huntington's . . . [Full Text of this Article]

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From the Center for Cancer Research, Massachusetts Institute of Technology, Bldg. E17, Rm. 543, 40 Ames St., Cambridge, MA 02139, where reprint requests should be addressed to Dr. Housman.

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