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Previous Volume 332:330-331 February 2, 1995 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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More than 40 years after the initial report¹ of a beneficial effect of aminopterin, the parent compound of methotrexate, in rheumatoid arthritis and psoriasis, there is a resurgence of interest in the use of methotrexate in autoimmune and inflammatory diseases. In this issue of the Journal, Feagan and colleagues report that in a 16-week double-blind trial, intramuscular methotrexate (25 mg once weekly) was more effective than placebo in improving symptoms and reducing requirements for prednisone in patients with chronically active Crohn's disease.² A greater proportion of patients were in clinical remission in the methotrexate group (39.4 percent) than in the . . . [Full Text of this Article]

References

Related Letters:

Methotrexate for Chronic Diseases in Adults
Fogari R. A., Hoch S., Zonneveld I.M., Bos J.D., Weinblatt M. E.
Extract | Full Text  
N Engl J Med 1995; 332:1791-1792, Jun 29, 1995. Correspondence

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