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Original Article
Brief Report
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Volume 332:367-369 February 9, 1995 Number 6
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Transplantation of Cord-Blood Stem Cells into a Patient with Severe Thalassemia
Surapol Issaragrisil, M.D., Sanan Visuthisakchai, M.D., Vinai Suvatte, M.D., Ph.D., Voravarn S. Tanphaichitr, M.D., M.S., Dasnayanee Chandanayingyong, M.D., Thomas Schreiner, M.D., Sujin Kanokpongsakdi, M.D., Noppadol Siritanaratkul, M.D., and Anong Piankijagum, M.D., Ph.D.

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Several different kinds of thalassemia and hemoglobinopathy are prevalent in Southeast Asia.1,2 The frequency of the {alpha}-thalassemias reaches 30 to 40 percent in northern Thailand, whereas the {beta}-thalassemias occur at a frequency of 3 to 9 percent. Hemoglobin E, the hallmark hemoglobinopathy of Southeast Asia, occurs at a frequency of 50 to 60 percent at the junction of Thailand, Laos, and Cambodia. Mutation and gene interaction account for more than 60 different clinical syndromes. Of these, homozygous {beta}-thalassemia and hemoglobin E –{beta}-thalassemia disease are the most common and the most severe clinical syndromes compatible with live birth. Hemoglobin E–{beta}. . . [Full Text of this Article]

Case Report

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From the Chulabhorn Bone Marrow Transplant Center (S.I., S.V.), and the Departments of Medicine (S.I., S.V., N.S., A.P.), Pediatrics (V.S., V.S.T.), Transfusion Medicine (D.C.), and Obstetrics and Gynecology (S.K.), Siriraj Hospital, Mahidol University, Bangkok, Thailand; and the Department of Transfusion Medicine, University of Ulm, Ulm, Germany (T.S.).

Address reprint requests to Professor Issaragrisil at the Department of Medicine, Siriraj Hospital, 2 Prannok, Bangkok 10700, Thailand.

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