Several different kinds of thalassemia and hemoglobinopathyare prevalent in Southeast Asia.1,2 The frequency of the -thalassemiasreaches 30 to 40 percent in northern Thailand, whereas the -thalassemiasoccur at a frequency of 3 to 9 percent. Hemoglobin E, the hallmarkhemoglobinopathy of Southeast Asia, occurs at a frequency of50 to 60 percent at the junction of Thailand, Laos, and Cambodia.Mutation and gene interaction account for more than 60 differentclinical syndromes. Of these, homozygous -thalassemia and hemoglobinE -thalassemia disease are the most common and the mostsevere clinical syndromes compatible with live birth. HemoglobinE. . . [Full Text of this Article]
Case Report
Methods
Results
Discussion
Source Information
From the Chulabhorn Bone Marrow Transplant Center (S.I., S.V.), and the Departments of Medicine (S.I., S.V., N.S., A.P.), Pediatrics (V.S., V.S.T.), Transfusion Medicine (D.C.), and Obstetrics and Gynecology (S.K.), Siriraj Hospital, Mahidol University, Bangkok, Thailand; and the Department of Transfusion Medicine, University of Ulm, Ulm, Germany (T.S.).
Address reprint requests to Professor Issaragrisil at the Department of Medicine, Siriraj Hospital, 2 Prannok, Bangkok 10700, Thailand.
References
This article has been cited by other articles:
Locatelli, F., Rocha, V., Reed, W., Bernaudin, F., Ertem, M., Grafakos, S., Brichard, B., Li, X., Nagler, A., Giorgiani, G., Haut, P. R., Brochstein, J. A., Nugent, D. J., Blatt, J., Woodard, P., Kurtzberg, J., Rubin, C. M., Miniero, R., Lutz, P., Raja, T., Roberts, I., Will, A. M., Yaniv, I., Vermylen, C., Tannoia, N., Garnier, F., Ionescu, I., Walters, M. C., Lubin, B. H., Gluckman, E.
(2003). Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease. Blood
101: 2137-2143
[Abstract][Full Text]
Reed, W., Smith, R., Dekovic, F., Lee, J. Y., Saba, J. D., Trachtenberg, E., Epstein, J., Haaz, S., Walters, M. C., Lubin, B. H.
(2003). Comprehensive banking of sibling donor cord blood for children with malignant and nonmalignant disease. Blood
101: 351-357
[Abstract][Full Text]
Greenberg, P. L., Gordeuk, V., Issaragrisil, S., Siritanaratkul, N., Fucharoen, S., Ribeiro, R. C.
(2001). Major Hematologic Diseases in the Developing World-- New Aspects of Diagnosis and Management of Thalassemia, Malarial Anemia, and Acute Leukemia. ASH Education Book
2001: 479-498
[Abstract][Full Text]
Olivieri, N. F.
(1999). The {beta}-Thalassemias. NEJM
341: 99-109
[Full Text]
Bogardus, S. T. Jr, Concato, J., Feinstein, A. R.
(1999). Clinical Epidemiological Quality in Molecular Genetic Research: The Need for Methodological Standards. JAMA
281: 1919-1926
[Abstract][Full Text]
Laporte, J.-P., Gorin, N.-C., Rubinstein, P., Lesage, S., Portnoi, M.-F., Barbu, V., Lopez, M., Douay, L., Najman, A.
(1996). Cord-Blood Transplantation from an Unrelated Donor in an Adult with Chronic Myelogenous Leukemia. NEJM
335: 167-170
[Full Text]
Gale, R. P.
(1995). Cord-Blood-Cell Transplantation -- A Real Sleeper?. NEJM
332: 392-395
[Full Text]