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Previous Volume 332:371-379 February 9, 1995 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Nearly 500,000 patients in the United States were treated with radiation in 1990,¹ making radiotherapy one of the most widely used treatments for cancer. In this article we discuss advances that have occurred since the subject of radiation oncology was last reviewed in the Journal, over a decade ago.² We begin by summarizing the biologic responses of cells to radiation, particularly as they relate to the development of new therapies. We then discuss developments in the physics of radiation therapy, especially the influence of high-speed computers and graphics displays on the accuracy of radiation treatment. Finally, we discuss clinical advances . . . [Full Text of this Article]

Radiation Biology

Cellular Perturbations

            Effects on Growth Factors and Signal-Transduction Pathways

            Apoptosis

            Changes in Cell-Cycle Regulation

Modifiers of the Response to Radiation

Physics of Radiation Therapy

Clinical Treatment

Radiation as Definitive Treatment (with or without Chemotherapy)

            Small-Cell Lung Cancer

            Anal Carcinoma

            Bladder Carcinoma

            Carcinoma of the Esophagus

            Head and Neck Cancer

Radiation for Organ Preservation after Limited Surgery

            Soft-Tissue Sarcomas of the Extremities

            Sphincter Preservation for Patients with Distal Rectal Carcinoma

Radiation as an Adjunct to Radical Surgery

            Rectal Carcinoma

            Chest-Wall Irradiation after Mastectomy

Palliation

Summary

Source Information

From the Department of Radiation Oncology, University of Michigan Medical Center, 1500 E. Medical Center Dr., Rm. AGH B2C490, Ann Arbor, MI 48109-0010, where reprint requests should be addressed to Dr. Lichter.

References

Related Letters:

Radiation Oncology
Nori D., Reddy N. M.S., Osian A. D., Lichter A. S., Lawrence T. S.
Extract | Full Text  
N Engl J Med 1995; 333:392-393, Aug 10, 1995. Correspondence

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