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As a clinician-scientist with a long-standing interest in coagulation disorders and thrombosis, I find it exciting that the molecular genetics of hemostasis now merits its own monograph. When i entered the field two decades ago, purification of even the most abundant coagulation proteins was an arduous task, and information on the primary sequence or gene structure of these proteins did not exist. Thanks to the molecular-biology revolution and the work of many academic and industrial laboratories, we now know a great deal about the structure and function of the coagulation proteins and the molecular basis of bleeding disorders.
Tuddenham and
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