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It is now more than 35 years since E.D. Thomas and coworkers reported in the Journal that large quantities of bone marrow could be safely infused into humans and that transient engraftment of hematopoietic cells was possible. That work germinated the seed that has grown into an important segment of modern medical practice, with bone marrow transplantation units no longer limited to a few academic centers. The success of the procedure in curing genetic and malignant diseases (albeit tempered by the remaining long road to achieving the goals of minimal toxicity and maximal efficacy) has resulted in dramatically increased use
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