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Previous Volume 332:507-510 February 23, 1995 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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We describe a patient with a unique mantle-cell lymphoma, with cycles of acute illness alternating with spontaneous remissions. During the acute phase the patient had fever, generalized lymphadenopathy, hepatosplenomegaly, increased liver-enzyme concentrations, leukocytosis, and thrombocytopenia. These bouts remitted after two to three weeks without treatment. Fifteen such cycles were documented over a period of 50 months.

During the acute phase blast-like B lymphocytes in the blood expressed surface IgM, IgD, and CD5, whereas during clinical remission a small population of IgM and CD5+ lymphocytes persisted. Two B-cell clones with differently rearranged heavy-chain genes consistently appeared in the blood during the . . . [Full Text of this Article]

Case Report

Methods

Results

The Identification of Two Clones

Spontaneous Apoptosis of the Lymphoma Cells Correlating with the Repeated Regressions of the Acute Phase

Discussion

Source Information

From the Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer (Y.K., A.M., G.R., O.M., M.B., E.R., M.L., J.D., I.A., Z.M., F.B.-S., B.R.), and the Sackler School of Medicine, Tel Aviv University, Tel Aviv (Y.K., A.M., G.R., F.B.-S., B.R.) — both in Israel.

Address reprint requests to Dr. Kaufmann at the Hematology Institute, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel.

References

Related Letters:

Relapsing Lymphoma
Beun G. D.M., Vlasveld L. T., van 't Veer M. B., Kaufmann Y., Many A.
Extract | Full Text  
N Engl J Med 1995; 333:194-195, Jul 20, 1995. Correspondence

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• Bogardus, S. T. Jr, Concato, J., Feinstein, A. R. (1999). Clinical Epidemiological Quality in Molecular Genetic Research: The Need for Methodological Standards. JAMA 281: 1919-1926 [Abstract] [Full Text]  
• Beun, G. D.M., Vlasveld, L. T., van 't Veer, M. B., Kaufmann, Y., Many, A. (1995). Relapsing Lymphoma. NEJM 333: 194-195 [Full Text]