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Correspondence
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Volume 333:62-64 July 6, 1995 Number 1
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Intramuscular Injections and Vaccine-Associated Poliomyelitis

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 by Strebel, P. M.
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To the Editor: The report by Strebel et al. (Feb. 23 issue)1 provides support for our ongoing work on the role of the muscle and the participation of the poliovirus receptor in the transport of the poliovirus from the muscle to the motor neurons. The poliovirus receptor, an integral membrane protein with structural characteristics of the immunoglobulin superfamily of proteins,2 is the prerequisite for infection of tissue with the poliovirus. The possible entry of the virus into the central nervous system through muscle prompted us to search for the poliovirus receptor in normal human muscle fibers and motor end plates . . . [Full Text of this Article]

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