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The objective of this monograph is to inform the reader of recent anatomical and physiologic information that has radically altered our conception of infantile spasms. Clusters of axial spasms accompanied by at least transient developmental regression were first described by W.J. West in 1841. He carefully observed the progress and regression of the disorder in his infant son. For over a century this encephalopathy was considered a single epileptic entity with multiple causes probably originating in the brain stem and then disseminating through rostral projections to involve the cortices of both hemispheres. The thrust of this book is to review
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