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Previous Volume 333:645-647 September 7, 1995 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Hardly a month goes by without a report that some new gene for a human disease has been cloned. Recently, for example, the genes responsible for ataxia–telangiectasia and early-onset Alzheimer's disease were isolated. In the final analysis, such studies always come down to a DNA sequence and whatever biologic function (or functions) we can infer from it. In other words, we may know from genetic-linkage studies that a particular gene sequence (in mutated form) is responsible for a disease, but what clues can a DNA sequence provide about the precise pathophysiology of that disease? Overwhelmingly, the answer now lies in . . . [Full Text of this Article]

Source Information

From the National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, where reprint requests should be addressed to Dr. Boguski, who may also be reached by electronic mail (boguski@ncbi.nlm.nih.gov).

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