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Previous Volume 333:665-667 September 7, 1995 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Lockshin, M. D. Related Article by Khamashta, M. A. PubMed Citation

To the Editor: The finding by Khamashta et al. (April 13 issue)¹ supports those of two recent studies,^2,3 which demonstrated that patients with antiphospholipid antibodies are in an ongoing prothrombotic state. In this condition there are high plasma values of prothrombin fragment F₁+₂, a peptide derived from the conversion of prothrombin to thrombin and considered a marker of thrombin generation in vivo.

Even if Khamashta et al. show that the risk of bleeding with warfarin therapy is low, an important issue is whether all patients with antiphospholipid-antibody syndrome and a history of thrombosis should be treated with oral . . . [Full Text of this Article]

References

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• Hirsh, J., Fuster, V., Ansell, J., Halperin, J. L. (2003). American Heart Association/American College of Cardiology Foundation Guide to Warfarin Therapy. Circulation 107: 1692-1711 [Full Text]  
• Hirsh, J., Dalen, J. E., Anderson, D. R., Poller, L., Bussey, H., Ansell, J., Deykin, D. (2001). Oral Anticoagulants: Mechanism of Action, Clinical Effectiveness, and Optimal Therapeutic Range. Chest 119 : 8S-21S [Full Text]  
• Ansell, J., Hirsh, J., Dalen, J., Bussey, H., Anderson, D., Poller, L., Jacobson, A., Deykin, D., Matchar, D. (2001). Managing Oral Anticoagulant Therapy. Chest 119 : 22S-38S [Full Text]  
• Wahl, D G, Guillemin, F, de Maistre, E, Perret-Guillaume, C, Lecompte, T, Thibaut, G (1998). Meta-analysis of the risk of venous thrombosis in individuals with antiphospholipid antibodies without underlying autoimmune disease or previous thrombosis. Lupus 7: 15-22 [Abstract]  
• Hirsh, J., Hoak, J. (1996). Management of Deep Vein Thrombosis and Pulmonary Embolism : A Statement for Healthcare Professionals From the Council on Thrombosis (in Consultation With the Council on Cardiovascular Radiology), American Heart Association. Circulation 93: 2212-2245 [Full Text]