Polycystic Ovary Syndrome

doi:10.1056/NEJM199509283331307

A correction has been published: N Engl J Med 1995;333(21):1435.

Volume 333:853-861		September 28, 1995		Number 13

Polycystic Ovary Syndrome

Stephen Franks, M.D.

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Polycystic ovary syndrome — in its most typical form,the association of hyperandrogenism and chronic anovulation— is one of the most common endocrine disorders. The clinicaland biochemical features are heterogeneous, and there has beenmuch debate as to whether it represents a single disorder orseveral. In recent years, it has become apparent that the polycysticovary syndrome not only is the most frequent cause of anovulationand of hirsutism, but is also associated with a characteristicmetabolic disturbance (resistance to the action of insulin)that may have important implications for long-term health.

Definition

The most widely accepted clinical . . . [Full Text of this Article]

Prevalence

Clinical Presentation

Diagnosis and Differential Diagnosis

Endocrine Abnormalities

Gonadotropins

Androgens

Estrogens

Prolactin and Growth Hormone

Metabolic Abnormalities

Pathogenesis

Genetic Basis of the Syndrome

Management

Anovulation

Hyperandrogenism

Management of Metabolic Aspects of the Syndrome

Source Information

From the Reproductive Endocrinology Group, Department of Obstetrics and Gynaecology, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, University of London, London W2 IPG, United Kingdom, where reprint requests should be addressed to Dr. Franks.

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N Engl J Med 1996; 334:668-669, Mar 7, 1996. Correspondence

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